SAB4500493

Anti-p38 MAPK antibody produced in rabbit

affinity isolated antibody

• Sinónimos: MAP kinase MXI2, MAP kinase p38, MAPK14, kinase p38-α
• Número MDL: MFCD00803556
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: antigen 41 kDa
• reactividad de especies: human, rat, mouse
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; western blot: 1:500-1:1000
• Nº de acceso NCBI: Q16539
• Nº de acceso UniProt: Q16539
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... MAPK14(1432)

Descripción

Descripción general

Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein.

p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human p38 MAPK.

Immunogen Range: 147-196

Aplicación

Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis.

Acciones bioquímicas o fisiológicas

p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable