SAB4300361

Anti-ITGB3 (Ab-773) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-CD61 antibody produced in rabbit, Anti-GP3A antibody produced in rabbit, Anti-GPIIIa antibody produced in rabbit, Anti-integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody produced in rabbit
• Número MDL: MFCD00211790
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: IHC (p); WB
• clon: polyclonal
• reactividad de especies: human, rat, mouse
• citations: 4
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: ~110 kDa
• reactividad de especies: human, rat, mouse
• concentración: 1 mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotipo: IgG
• secuencia del inmunógeno: (P-L-Y-K-E)
• Nº de acceso NCBI: NP_000203.2
• Nº de acceso UniProt: P05106
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ITGB3(3690)

Descripción

Descripción general

ITGB3 (integrin subunit β3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.

Inmunógeno

Peptide sequence around aa. 771-775 (P-L-Y-K-E), according to the protein ITGB3.

Acciones bioquímicas o fisiológicas

Mutations in ITGB3 (integrin subunit β3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells, promoted by reactive oxygen species.

Características y beneficios

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Descripción de destino

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable