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Merck

SAB4200585

Sigma-Aldrich

Anti-ERGIC-53 antibody, Mouse monoclonal

clone ERGIC-3, purified from hybridoma cell culture

Sinónimos:

Monoclonal Anti-ER-Golgi intermediate compartment 53 kDa protein, Monoclonal Anti-ERGIC-53 antibody produced in mouse, Monoclonal Anti-ERGIC53, Monoclonal Anti-F5F8D, Monoclonal Anti-Gp58, Monoclonal Anti-Intracellular mannose-specific lectin MR60, Monoclonal Anti-LMAN1, Monoclonal Anti-Lectin mannose-binding 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified from hybridoma cell culture

tipo de anticuerpo

primary antibodies

clon

ERGIC-3, monoclonal

formulario

buffered aqueous solution

mol peso

antigen ~58 kDa

reactividad de especies

mouse, human, rat

concentración

~1 mg/mL

técnicas

immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.

isotipo

IgG1

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... LMAN1(3998)
mouse ... Lman1(70361)
rat ... Lman1(116666)

Descripción general

Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.

Inmunógeno

synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.

Acciones bioquímicas o fisiológicas

Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP+
Brill L B II, et al.
Experimental Neurology, 181(1), 25-38 (2003)
Two new mutations at ERGIC-53 gene in a Turkish family
Torun, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 248-250 (2011)
The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Klaus JP, et al.
Cell host & microbe, 14(5), 522-534 (2013)
Mariana L Ferrari et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13582-13591 (2019-06-19)
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium by the injection of virulence factors through a type
Xiang Gui et al.
Nature, 567(7747), 262-266 (2019-03-08)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK

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