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Merck

SAB4200462

Sigma-Aldrich

Anti-Claudin-1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Sinónimos:

Anti-CLD1, Anti-CLDN1, Anti-ILVASC, Anti-SEMP1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~23 kDa

reactividad de especies

human, rat

concentración

~1.0 mg/mL

técnicas

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat kidney.
western blot: 1.5-3.0 μg/mL using extracts of rat kidney (S1 fraction).

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CLDN1(9076)
rat ... Cldn1(65129)

Descripción general

Anti-Claudin-1 is produced in rabbit using as immunogen a synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. Claudin-1 (also known as CLDN1, senescence-associated epithelial membrane protein (SEMP1) and ILVASC) is a 22 kDa protein. It is expressed at high levels in kidney and liver and at lower levels in spleen, heart, brain, lung and testis. Claudins are located in both epithelial and endothelial cells in tissues. Claudins consist of four transmembrane domains and two extracellular loops, required to form tight junction strands. CLDN1 gene is located on human chromosome 3q28.

Inmunógeno

synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. The corresponding sequence is identical in rat claudin-1 and highly conserved (single amino acid substitution) in mouse claudin-1.

Aplicación

Anti-Claudin-1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting,

Acciones bioquímicas o fisiológicas

Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs), resulting in tumor differentiation and progression. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). It participates in the barrier formation of tight junction. It modulates the tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Taurine supplementation alleviates puromycin aminonucleoside damage by modulating endoplasmic reticulum stress and mitochondrial-related apoptosis in rat kidney
Stacchiotti A, et al.
Nutrients, 10(6), 689-689 (2018)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
Test, jbc-M110 (2010)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
The Journal of biological chemistry, jbc-M110 (2010)
Claudin association with CD81 defines hepatitis C virus entry
Harris HJ, et al.
The Journal of Biological Chemistry, jbc-M110 (2010)
Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags
Hackl MJ, et al.
Nature Medicine, 19(12), 1661-1661 (2013)

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