SAB4200266

Anti-PP2A, C subunit antibody, Mouse monoclonal

clone 7A6, purified from hybridoma cell culture

• Sinónimos: MonoclonalAnti-PP2Ac, MonoclonalAnti-PP2CA, MonoclonalAnti-PP2Calpha, MonoclonalAnti-PPP2CA, MonoclonalAnti-RP-C, MonoclonalAnti-protein phosphatase 2, catalytic subunit, alpha isozyme
• Código UNSPSC: 12352203
• NACRES: NA.44

Propiedades

• origen biológico: mouse
• conjugado: unconjugated
• forma del anticuerpo: purified from hybridoma cell culture
• tipo de anticuerpo: primary antibodies
• clon: 7A6, monoclonal
• formulario: buffered aqueous solution
• mol peso: antigen 36 kDa
• reactividad de especies: human, mouse, rat
• concentración: ~1.0 mg/mL
• técnicas: immunoprecipitation (IP): suitable; western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat Rat2 or human A431 cells.
• isotipo: IgG1
• Nº de acceso UniProt: P67775
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PPP2CA(5515) ; mouse ... Ppp2ca(19052) ; rat ... Ppp2ca(24672)

Descripción

Descripción general

PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates localization of Sgo1 at centromeres, Ras-1 activation, and chromosome segregation. The catalytic subunit of PP2A (PP2Ac) regulates the signaling pathway for glucose-stiμLated insulin secretion .

Especificidad

Monoclonal Anti-PP2Ac is specific for the α and β isoforms of PP2Ac in humans, rats and mice. The antibody has not been tested in other species for cross-reactivity.

Aplicación

MonoclonalAnti-PP2A, C subunit antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

Acciones bioquímicas o fisiológicas

Protein phosphatase 2A (PP2A) is implicated in the negative control of cell growth and division. PP2Ac undergoes two post-translational modifications, phosphorylation and methylation, which are involved in the regulation of the enzyme activity.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable