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Merck

SAB4200203

Sigma-Aldrich

Anti-RAVER1 antibody, Mouse monoclonal

clone RAV1, purified from hybridoma cell culture

Sinónimos:

Anti-Ribonucleoprotein PTB-binding 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
IP
WB CL
clon:
RAV1, monoclonal
reactividad de especies:
human, monkey
citations:
3
técnicas:
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1.0-2.0 μg/mL using HeLa or HepG2 cells extract

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified from hybridoma cell culture

tipo de anticuerpo

primary antibodies

clon

RAV1, monoclonal

Formulario

buffered aqueous solution

mol peso

antigen ~80 kDa

reactividad de especies

human, monkey

concentración

~1.0 mg/mL

técnicas

immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1.0-2.0 μg/mL using HeLa or HepG2 cells extract

isotipo

IgG1

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... RAVER1(125950)

Descripción general

Monoclonal Anti-RAVER1 (mouse IgG1 isotype) is derived from the hybridoma RAV1 produced by the fusion of mouse myeloma cells (NS1) and splenocytes from mouse immunized with a peptide corresponding to a fragment of human RAVER1. Raver1, also known as ribonucleoprotein PTB-binding 1, is a widely expressed multidomain protein, identified in two-hybrid screens by its ability to interact and colocalize with the cytoskeletal proteins -actinin and vinculin. The protein is composed of three RNA recognition motifs (RRM) and of nuclear localization and nuclear export signals, allowing it to shuttle between the nucleus and the cytoplasm. Raver1 also colocalizes with PTB/hnRNPI.

Aplicación

Monoclonal Anti-RAVER1 antibody produced in mouse has been used in immunoblotting.

Acciones bioquímicas o fisiológicas

RAVER1 (ribonucleoprotein, PTB binding 1) is involved in RNA splicing of microfilament proteins. In skeletal muscle, a translocation of Raver1 from the nucleus to the cytoplasm is correlated with the differentiation of specific microfilament attachment sites. Based on an analysis of Vinculin-Raver1 crystal structure it was suggested that vinculin recruits raver1 and its mRNAs cargo to focal adhesions, promoting localization of the synthesis of adhesion complexes by the translational machinery.

Forma física

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins
Huttelmaier, et al.
The Journal of Cell Biology, 155, 775-775 (2001)
Raver1 Interactions with Vinculin and RNA Suggest a Feed-Forward Pathway in Directing mRNA to Focal Adhesions
Lee J H, et al.
Structure, 17, 833-842 (2009)
K Meletis et al.
The Journal of cell biology, 155(5), 699-702 (2001-11-29)
Recent studies have shown that cells expressing neuronal antigens can be derived from a bone marrow transplant. A new report lends support to and extends these previous results by presenting compelling morphological evidence for the generation and integration of highly

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