SAB3500428

Anti-DR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-TRAIL-R1
• Número MDL: MFCD01864349
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: predicted mol wt 56 kDa
• reactividad de especies: human
• técnicas: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Nº de acceso NCBI: AAC51226
• Nº de acceso UniProt: O00220
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TNFRSF10A(8797)

Descripción

Descripción general

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

Inmunógeno

DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

Aplicación

Anti-DR4 antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.

Características y beneficios

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Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500428.

Forma física

Supplied in PBS with 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable