SAB2702364

Monoclonal Anti-Iba1 antibody produced in mouse

clone GT10312, affinity isolated antibody

• Sinónimos: AIF-1, IBA1, IRT-1, IRT1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: GT10312, monoclonal
• formulario: buffered aqueous solution
• mol peso: 17kDa
• reactividad de especies: mouse, human, rat
• concentración: 2.03mg/mL
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000; indirect immunofluorescence: suitable; western blot: 500-3000
• isotipo: IgG1
• Nº de acceso UniProt: P55008
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... AIF1(199)

Descripción

Descripción general

Ionized calcium-binding adapter molecule 1 (IBA1), also called the allograft inflammatory factor 1 (AIF1) is mapped to human chromosome 6p21.33. It encodes a 17 kDa protein and comprises calcium binding EF hand motif. IBA1 is expressed in lung, tonsil, lymph node and spleen. In addition,it is also expressed in macrophages and glial cells.

Inmunógeno

Recombinant protein encompassing a sequence within the center region of human Iba1.

Aplicación

Monoclonal Anti-Iba1 antibody produced in mouse has been used:

• in the double immunofluorescence
• in the immunofluorescence
• in immunohistochemistry

Acciones bioquímicas o fisiológicas

Ionized calcium-binding adapter molecule 1 (IBA1) interacts with filamentous actin (F‐actin) and L‐fimbrin. Its expression is modulated during injury. Inflammatory cytokines also induce IBA1 expression. IBA1 expression is implicated in the graft rejection in coronary artery vasculopathy (CAV). It is highly expressed in hepatocellular carcinoma and may serve a potential marker and therapeutic target. Increased expression of AIF1 in synovial fluid and peripheral blood monocytes is implicated in rheumatoid arthritis.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Otras notas

Purification: Affinity purified by Protein G

Forma física

Phosphate-buffered saline, no preservative added.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable