SAB2501506

Anti-ZCCHC11 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-KIAA0191, Anti-bHLHa22, CCHC domain containing 11, PAP associated domain containing 3, Zinc finger
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA (i); IF; IHC
• clon: polyclonal
• reactividad de especies: canine, bovine, human, rat, mouse
• citations: 4
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable

Propiedades

• origen biológico: goat
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: canine, bovine, human, rat, mouse
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable
• Nº de acceso UniProt: Q5TAX3
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ZCCHC11(23318)

Descripción

Descripción general

Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.

Inmunógeno

Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1

Acciones bioquímicas o fisiológicas

Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.

Características y beneficios

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Forma física

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable