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SAB1411757

Sigma-Aldrich

Anti-VEGFC antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Sinónimos:

Flt4-L, VRP

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen 46.09 kDa

reactividad de especies

human

técnicas

western blot: 1 μg/mL

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... VEGFC(7424)

Descripción general

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. (provided by RefSeq)
The vascular endothelial growth factor-C (VEGF-C) gene with seven exons is mapped to human chromosome 4q34.3. It is a member of the VEGF family of structurally related proteins. Members of the family contain a common VEGF homology domain. This domain forms the core region and contains a cystine knot motif with eight invariant cysteine residues. In adults, VEGF-C is mainly expressed in heart, placenta, ovary, small intestine and the thyroid gland, whereas in embryonic tissue, it is expressed in the perimetanephric, axillary and jugular areas.

Inmunógeno

VEGFC (ABM85407.1, 1 a.a. ~ 419 a.a) full-length human protein.

Sequence
MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS

Acciones bioquímicas o fisiológicas

VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions through the VEGF receptor-3 (VEGFR-3). Experimental studies have shown that VEGF-C is required for lymphatic endothelial cells to form sprouting capillaries. VEGF-C expression has been observed in breast cancer, prostatic cancer, gastric cancer, colon cancer and lung cancer.

Forma física

Solution in phosphate buffered saline, pH 7.4

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.
Liersch R
International Journal of Oncology, 41, 2073-2078 (2012)
Vascular Endothelial Growth Factor and Angiogenesis
Hoeben A
Pharmacological Reviews, 56, 549-580 (2004)
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy
Aldebasi YH
International Journal of Clinical and Experimental Medicine, 6, 239-251 (2013)
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors.
Tuomela J, et al.
BMC Cancer (2009)
Jing Hu et al.
European journal of cancer (Oxford, England : 1990), 50(13), 2336-2350 (2014-07-09)
Recent studies have indicated that microRNAs (miRNAs) are important gene regulators that play critical roles in biological processes and function as either tumour suppressors or oncogenes. Therefore, the expression levels of miRNAs can be important and reliable biomarkers for cancer

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