SAB1300449

Anti-DGKZ (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-ζ, Anti-DAG kinase ζ, Anti-DGK-ζ, Anti-Diacylglycerol kinase, Anti-Diglyceride kinase
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA (i); IHC; WB
• clon: polyclonal
• reactividad de especies: human
• citations: 5
• técnicas: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; western blot: 1:100-1:500

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; western blot: 1:100-1:500
• Nº de acceso NCBI: NP_963290
• Nº de acceso UniProt: Q13574
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... DGKZ(8525)

Descripción

Descripción general

Diacylglycerol kinase zeta ζ (DGKZ) belongs to the diacylglycerol kinase family. It is expressed in the central nervous system and comprises a nuclear localization signal, ankyrin repeats, and a PDZ-binding motif. DGKZ gene is localized on human chromosome 11p11.2.

Inmunógeno

DGKZ (NP_963290, 994-1029)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGKZ.

Acciones bioquímicas o fisiológicas

Diacylglycerol kinase zeta ζ (DGKZ) plays a key role in brain development. It mediates the conversion of diacylglycerol to phosphatidic acid. Elevated DGKZ levels is observed in human metastatic colon cancer. DGKZ protein defects are implicated in osteogenesis imperfecta (OI) leading to a phenotype characterized by fractures in utero and after birth, callus formation, and beaded ribs. DGKZ also regulates bone homeostasis. Knockdown of the DGKζ gene leads to cell cycle arrest and apoptosis in glioma cells.

Forma física

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable