ABT280

Anti-Periostin (Pan) Antibody

0.5 mg/mL, from rabbit

• Sinónimos: Periostin, PN, Osteoblast-specific factor 2, OSF-2
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse
• concentración: 0.5 mg/mL
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_001185694
• Nº de acceso UniProt: Q62009
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Postn(50706)

Descripción

Descripción general

Periostin, also known as PN, or Osteoblast-specific factor 2 (OSF-2), and encoded by the gene POSTN/OSF2, is a secreted extracellular matrix protein that appears to be involved in inducing cell attachment and spreading as well as cell adhesion. In bone, Periostin enhances mineralization and assists in the incorporation of BMP1 protein into the fibronectin extracellular matrix of connective tissues. Periostin is preferentially expressed in periosteum and periodontal ligaments but can also be found expressed in developing heart and other tissues. Periostin is also over expressed in many cancers where is contributes to a growth-supportive role for such cancers and also aids in chemoresistance for cancers cells through the activation of the PI3K/Akt/surviving pathway.

Especificidad

This antibody detects all splice variants of Periostin.

Inmunógeno

Linear peptide from the fasciclin 1 domain of mouse periostin.

Aplicación

Anti-Periostin (Pan) Antibody is an antibody against Periostin (Pan) for use in western blotting & IHC.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

Western Blotting Analysis: A representative lot detected Periostin (Pan) in mouse lung extract.

Immunohistochemistry Analysis: A representative lot detected Periostin (Pan) in certain reported tissues (Kruzynska-Frejtag, A., et al. (2004). Dev Dyn. 229(4):857-868.; Butcher, J. T., et al. (2007). Dev Biol. 302(1):256-266.; Norris, R. A., et al. (2007). J Cell Biochem. 101(3):695-711.; Inai, K., et al. (2008). Dev Biol. 315(2):383-396.; Norris, R. A., et al. (2008). Dev Biol. 316(2):200-213.).

Calidad

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Periostin (Pan) in 10 µg of mouse lung tissue lysate.

Descripción de destino

~75-85 kDa observed. Uniprot describes five isoforms at 93 kDa, 90 kDa, 90 kDa, 87 Kda, and 87 kDa However, this protein has been observed between 75-85 kDa

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing PBS.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable