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S8010

Sigma-Aldrich

(±)-Sulpiride

Sinónimos:

(±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide

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About This Item

Fórmula empírica (notación de Hill):
C15H23N3O4S
Número de CAS:
15676-16-1
Peso molecular:
341.43
Número CE:
239-753-7
Número MDL:
MFCD00055061
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24277933
NACRES:
NA.77

Formulario

powder

Nivel de calidad

100

color

white

solubilidad

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
0.1 M HCl: soluble
H2O: slightly soluble
ethanol: soluble

emisor

Sanofi Aventis

temp. de almacenamiento

2-8°C

cadena SMILES

CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O

InChI

1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

Clave InChI

BGRJTUBHPOOWDU-UHFFFAOYSA-N

Información sobre el gen

human ... CA1(759) , CA2(760) , CA4(762) , CA5A(763) , CA5B(11238) , CA9(768) , DRD2(1813)

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Aplicación

(±)-Sulpiride was used to study the effect of dopamine D2 receptor signaling on calcium channels in rat pituitary melanotropic cells.47

Acciones bioquímicas o fisiológicas

(±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46

Características y beneficios

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Reconstitución

Solutions may be stored for several days at 4 °C.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H361

Clasificaciones de peligro

Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCC9209
BCBR3633V
BCBR3633
BCBM2992V
BCBM2992

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Loxapine succinate United States Pharmacopeia (USP) Reference Standard

USP

1370702

Loxapine succinate

Amisulpride British Pharmacopoeia (BP) Reference Standard

BP1090

Amisulpride

Brinzolamide ≥98% (HPLC)

Sigma-Aldrich

SML0216

Brinzolamide

Dorzolamide ≥98% (HPLC)

Sigma-Aldrich

SML0468

Dorzolamide

S(−)-Raclopride (+)-tartrate salt >97%, solid

Sigma-Aldrich

R121

S(−)-Raclopride (+)-tartrate salt

R Shiloh et al.
The British journal of psychiatry : the journal of mental science, 171, 569-573 (1998-03-31)
We hypothesised that a combined regimen of clozapine, a relatively weak D2-dopaminergic antagonist, and sulpiride, a selective D2 blocker, would demonstrate a greater antipsychotic efficacy by enhancing the D2 blockade of clozapine. Twenty-eight people with schizophrenia, previously unresponsive to typical
Stephen Z Levine et al.
Schizophrenia research, 145(1-3), 125-127 (2013-02-12)
The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the
J A Keja et al.
The Journal of physiology, 450, 409-435 (1992-05-01)
1. Whole-cell voltage clamp recordings were made from 141 rat pituitary melanotropic cells in short-term, serum-free, primary culture. The effects of the dopamine D2 receptor agonist, LY 171555, on sodium, potassium and barium currents were investigated. 2. Application of 1
Giuseppina De Simone et al.
Journal of medicinal chemistry, 49(18), 5544-5551 (2006-09-01)
An approach for designing bioreductive, hypoxia-activatable carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the tumor-associated isoforms is reported. Sulfonamides incorporating 3,3'-dithiodipropionamide/2,2'-dithiodibenzamido moieties were prepared and reduced enzymatically/chemically in conditions present in hypoxic tumors, leading to thiols. The X-ray crystal structure
Erin M Leonard et al.
International journal of molecular sciences, 21(15) (2020-08-06)
Dopamine (DA) is a well-studied neurochemical in the mammalian carotid body (CB), a chemosensory organ involved in O2 and CO2/H+ homeostasis. DA released from receptor (type I) cells during chemostimulation is predominantly inhibitory, acting via pre- and post-synaptic dopamine D2
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