S0149

Streptolysin O from Streptococcus pyogenes

γ-irradiated

• Número de CAS: 98072-47-0
• Número CE: 308-500-3
• Número MDL: MFCD00132389
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• origen biológico: Streptococcus pyogenes
• Nivel de calidad: 200
• esterilidad: γ-irradiated
• Formulario: lyophilized powder
• aplicaciones: cell analysis
• temp. de almacenamiento: 2-8°C
• Información sobre el gen: Streptococcus pyogenes ... slo(900490)

Descripción

Aplicación

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.

Acciones bioquímicas o fisiológicas

Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.

Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

Thiol-activated toxin that permeabilizes animal cell membranes..

Definición de unidad

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Nota de preparación

Prepared from S 5265

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330
• Consejos de prudencia: P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)