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PZ0233

Sigma-Aldrich

PF-06424439

≥98% (HPLC)

Sinónimos:

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

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About This Item

Fórmula empírica (notación de Hill):
C22H26ClN7O · CH3SO3H
Número de CAS:
1469284-79-4
Peso molecular:
536.05
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329823784

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D +7 to +11°, c = 1.0 in methanol

color

white to light brown

solubilidad

H2O: 10 mg/mL, clear

temp. de almacenamiento

room temp

cadena SMILES

O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O

InChI

1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1

Clave InChI

ZSTFDNQQOJUJFL-XFULWGLBSA-N

Aplicación

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:
  • to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
  • to study its effects on HeLa cells
  • to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Acciones bioquímicas o fisiológicas

PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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