PZ0192

Bosutinib

≥98% (HPLC)

• Sinónimos: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile, SKI-606, WAY-173606
• Fórmula empírica (notación de Hill): C₂₆H₂₉Cl₂N₅O₃
• Número de CAS: 380843-75-4
• Peso molecular: 530.45
• Número MDL: MFCD07367846
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329823766
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: off-white to light brown
• solubilidad: DMSO: ≥15 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
• InChI: 1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
• Clave InChI: UBPYILGKFZZVDX-UHFFFAOYSA-N
• Información sobre el gen: human ... ABL1(25) , HCK(3055) , LYN(4067) , SRC(6714)

Descripción

Descripción general

Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML). It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate.

Acciones bioquímicas o fisiológicas

Bosutinib (SKI-606) is an orally active; dual Src/Abl tyrosine kinase inhibitor with potent antiproliferative activity. It does not appear to inhibit c-Kit and PDGRF, which are thought to be the cause of numerous side effects in anticancer treatment with some other tyrosine kinase inhibitors.

Orally active, dual Src/Abl kinase inhibitor with potent antiproliferative activity

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Otras notas

Sigma-Aldrich is a licensed supplier of Bosutinib, providing the authentic Pfizer compound. The material is independently assayed and verified by both Pfizer and Sigma-Aldrich.

Información legal

Sold for research purposes under agreement from Pfizer Inc.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319,H413
• Consejos de prudencia: P273 - P305 + P351 + P338
• Clasificaciones de peligro: Aquatic Chronic 4 - Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable