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Key Documents

Otros documentos

PZ0181

Sigma-Aldrich

PD184352

≥98% (HPLC)

Sinónimos:

2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040

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About This Item

Fórmula empírica (notación de Hill):
C17H14ClF2IN2O2
Número de CAS:
212631-79-3
Peso molecular:
478.66
Número MDL:
MFCD02683961
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
329823755
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

white to tan

solubilidad

DMSO: ≥30 mg/mL

temp. de almacenamiento

room temp

cadena SMILES

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

Clave InChI

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Información sobre el gen

human ... MAP2K1(5604) , MAP2K2(5605)

Acciones bioquímicas o fisiológicas

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Environment
GHS09

Palabra de señalización

Warning

Frases de peligro

H400

Consejos de prudencia

P273 - P391 - P501

Clasificaciones de peligro

Aquatic Acute 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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Sigma-Aldrich

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YC-1 powder

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Supelco

Supelco

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Adsorbente Carbopack™

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