P3134

Phosphodiesterase I from Crotalus adamanteus venom

Type VI, crude dried venom

• Sinónimos: 5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
• CAS Number: 9025-82-5
• Número CE: 3.1.4.1 (BRENDA, IUBMB)
• Número CE: 232-806-5
• Número MDL: MFCD00131883
• Código UNSPSC: 12352204
• NACRES: NA.54

Propiedades

• tpo: Type VI
• Nivel de calidad: 200
• Formulario: crude dried venom
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.

Aplicación

Phosphodiesterase I from Crotalus adamanteus venom has been used:

• for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
• as a model for the hydrolysis of prodrugs in phosphodiesterase assay
• as a component in the nucleotide cleavage buffer

Acciones bioquímicas o fisiológicas

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca²⁺/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H334
• Consejos de prudencia: P261 - P284 - P501
• Clasificaciones de peligro: Resp. Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable