P0778

Pindolol

≥98% (TLC), powder

• Sinónimos: 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• Fórmula empírica (notación de Hill): C₁₄H₂₀N₂O₂
• Número de CAS: 13523-86-9
• Peso molecular: 248.32
• Número CE: 236-867-9
• Número MDL: MFCD00010530
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277795
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: powder
• color: white to off-white
• mp: 167-171 °C (lit.)
• solubilidad: 0.1 M NaOH: 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL; 0.1 M HCl: 20 mg/mL; acetic acid: 50 mg/mL; H₂O: insoluble
• emisor: Novartis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• Clave InChI: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• Información sobre el gen: human ... ADRB1(153) , ADRB2(154) , HTR1A(3350)

Descripción

Aplicación

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Acciones bioquímicas o fisiológicas

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

Características y beneficios

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315,H319,H335
• Consejos de prudencia: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves