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Merck
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Key Documents

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N1790

Sigma-Aldrich

Naftifine hydrochloride

Sinónimos:

Naftifine HCL

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About This Item

Fórmula empírica (notación de Hill):
C21H21N · HCl
Número de CAS:
65473-14-5
Peso molecular:
323.86
Número MDL:
MFCD00059047
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
329818590
NACRES:
NA.76

Análisis

≥99%

formulario

powder

solubilidad

ethanol: soluble 50 mg/mL

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria
fungi
yeast

Modo de acción

cell wall synthesis | interferes
enzyme | inhibits

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23

InChI

1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;

Clave InChI

OLUNPKFOFGZHRT-YGCVIUNWSA-N

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Aplicación

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Acciones bioquímicas o fisiológicas

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Michael H Gold et al.
Skinmed, 9(5), 283-286 (2011-12-15)
Tinea versicolor (TV) is a superficial cutaneous fungal infection characterized by cutaneous pigment changes, pruritus, scaling, and erythema. This open-label, single-center pilot study evaluated the efficacy and safety of naftifine 1% gel applied twice daily for 2 weeks in 10
Lawrence Charles Parish et al.
Journal of drugs in dermatology : JDD, 10(10), 1142-1147 (2011-10-05)
Naftifine HCl 2% cream (NAFT-2%) is a topical allylamine antifungal preparation under development in the U.S. The objective of this randomized, double-blind, vehicle-controlled study was to evaluate the efficacy and safety of a two-week course of once-daily NAFT-2% vs. vehicle
Naftifine, a topical allylamine.
Shellie Marks et al.
Journal of drugs in dermatology : JDD, 9(7), 750-750 (2010-08-04)
[The problem of external therapy used in skin mycosis].
G N Tarasenko et al.
Voenno-meditsinskii zhurnal, 325(8), 38-39 (2004-10-09)
Aditya K Gupta et al.
Journal of cutaneous medicine and surgery, 12(2), 51-58 (2008-03-19)
Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also
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