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Merck

N0513

Sigma-Aldrich

Nerve Growth Factor-7S from murine submaxillary gland

lyophilized powder, suitable for cell culture

Sinónimos:

NGF-7S

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

product name

Nerve Growth Factor-7S from murine submaxillary gland, NGF-7S, lyophilized powder, suitable for cell culture

origen biológico

mouse

formulario

lyophilized powder

potencia

2-250 ng/mL ED50/EC50

calidad

endotoxin tested

mol peso

protein 130 kDa

envase

pkg of 0.1 mg

técnicas

cell culture | mammalian: suitable

impurezas

≤10

color

white

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... Ngf(18049)

Descripción general

Nerve growth factor (NGF) is a dimer of 118-residue polypeptide chains linked non-covalently. Both these polypeptides contain three intramolecular disulphide bridges. It forms the prototype of the neurotrophin growth factor family. In male mouse submandibular salivary gland, NGF is present in high amounts, and is present as a high molecular weight complex called nerve growth factor-7S (NGF-7S). NGF-7S is an α2β2γ2 complex, where β2-NGF is the active neurotrophin, and is linked to the dimers of the glandular kallikrein serine proteinases members, α-NGF and γ-NGF.

Aplicación

Nerve Growth Factor-7S (NGF-7S) from murine submaxillary gland has been used for the treatment of following cells to induce neuronal differentiation-
  • PC12
  • Dorsal root ganglia (DRG) obtained from chick embryos of either sex (Gallus gallus)

Acciones bioquímicas o fisiológicas

Nerve growth factor (NGF) is a neurotrophin, which facilitates the differentiation and survival of specific subtypes of neurons of central nervous system and peripheral nervous system. However, nerve growth factor-7S (NGF-7S) lacks any neurotrophic activity as most part of β-NGF subunit is buried within the NGF-7S complex.

Forma física

Lyophilized from 0.2 μm filtered solution in 25 mM sodium phosphate, pH 7.0.

Nota de preparación

Nerve growth factor-7S (NGF-7S) is isolated from male mouse submaxillary glands using a modification of the method of Varon, et al.

Nota de análisis

The biological activity is measured using a 3-day MTT assay.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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