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Merck

N8133

Sigma-Aldrich

Nerve Growth Factor from Vipera lebetina venom

NGF, lyophilized powder, suitable for cell culture

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

origen biológico

Vipera Lebetina

Nivel de calidad

formulario

lyophilized powder

potencia

0.2-20 μg/mL ED50/EC50

calidad

endotoxin tested

mol peso

protein 32.5 kDa

envase

pkg of 0.1 mg

técnicas

cell culture | mammalian: suitable

impurezas

<10 EU/vial

color

white to off-white

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Forma física

Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.

Nota de preparación

Isolated from the snake venom of V. lebetina.

Nota de análisis

The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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A growing number of studies are revealing that cells can send and receive information by controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we discuss what is known about the dynamics of various signaling networks and
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Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. However, the in vivo consequences of Trk ubiquitination remain to be addressed. We have developed a mouse model with a mutation in the
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Journal of cellular physiology, 229(6), 783-790 (2013-10-30)
The peripheral application of the M2 cholinergic agonist arecaidine on sensory nerve endings shows anti-nociceptive properties. In this work, we analyze in vitro, the mechanisms downstream M2 receptor activation causing the analgesic effects, and in vivo the effects produced by
Yu-Jung Chang et al.
Biochimica et biophysica acta, 1830(8), 4130-4136 (2013-04-16)
Neurotrophins are important regulators for neural development and regeneration. Nerve growth factor (NGF) therapy has been tested in various models of neural injury and degeneration. However, whether NGF can reach target tissues and maintain effective concentration for a certain period
M Florencia Iulita et al.
Trends in pharmacological sciences, 35(7), 338-348 (2014-06-26)
Alzheimer's disease (AD) is a devastating neurodegenerative condition and the most common type of amnestic dementia in the elderly. Individuals with Down syndrome (DS) are at increased risk of developing AD in adulthood as a result of chromosome 21 trisomy

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