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M4699

Sigma-Aldrich

MTEP hydrochloride

≥98% (HPLC)

Sinónimos:

MTEP hydrochloride, 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C11H8N2SHCl
Número de CAS:
1186195-60-7
Peso molecular:
236.72
Número MDL:
MFCD08458895
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329817993
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: 30 mg/mL, clear

emisor

Merck & Co., Inc., Kenilworth, NJ, U.S.

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.Cc1nc(cs1)C#Cc2cccnc2

InChI

1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H

Clave InChI

YCIOJDKGCWAHLR-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

MTEP is a potent and highly selective antagonist for mGluR5.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
044M4755V
021M4707V

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Rianne R Campbell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(14), 2745-2761 (2019-02-10)
The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we used a combination of
Kathy Sengmany et al.
Neuropharmacology, 149, 83-96 (2019-02-15)
Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5) have been proposed as potential therapies for various CNS disorders. These ligands bind to sites distinct from the orthosteric (or endogenous) ligand, often with improved subtype selectivity and spatio-temporal control
Carla Ferrada et al.
Neuroreport, 28(1), 28-34 (2016-11-22)
The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical
Richard M Cleva et al.
Frontiers in pharmacology, 2, 93-93 (2012-01-11)
Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function
Tomas Ondrejcak et al.
Neurobiology of disease, 127, 582-590 (2019-03-27)
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechanisms, including long-term depression (LTD), is posited to
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