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Merck

A9101

Sigma-Aldrich

Acetylcholine chloride

≥99% (TLC), powder or crystals

Sinónimos:

ACh

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About This Item

Fórmula lineal:
(CH3)3N+CH2CH2OCOCH3Cl-
Número de CAS:
Peso molecular:
181.66
Beilstein:
3571875
Número CE:
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.32

product name

Acetylcholine chloride, pkg of 150 mg (per vial)

Análisis

≥99% (TLC)

Nivel de calidad

formulario

powder or crystals

envase

pkg of 150 mg (per vial)

mp

146-150 °C (lit.)

solubilidad

H2O: soluble

temp. de almacenamiento

room temp

cadena SMILES

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

Clave InChI

JUGOREOARAHOCO-UHFFFAOYSA-M

Información sobre el gen

human ... CHRM3(1131)

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Descripción general

Acetylcholine is an important neurotransmitter that plays a critical role in multiple neurological systems. Crucial for neurobiology studies, acetylcholine aids researchers in understanding synaptic transmission. In other forms of research, acetylcholine has an effect and influence on tumor neurobiology for cancer R&D, as well as a variety of other cognitive processes.

Aplicación

For use as a substrate to determine acetylcholinesterase activity. Acetylcholine chloride has been used:
  • for standard curve preparation in hestrin assay
  • in Protein expression, radioactive ligand binding assay and electrophysiological studies of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBPs)
  • as a supplement in extracellular solutions for treating the voltage clamped cells in electrophysiology studies

Acciones bioquímicas o fisiológicas

Acetyl choline (ACh) is an essential neurotransmitter in both central and peripheral nervous system. ACh binds to nicotinic acetylcholine receptors (nAChRs) and causes fast excitatory neurotransmission.
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Reconstitución

Reconstituted solution is stable for 2 weeks when stored at 2-8 °C

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Evaluation of two WHO First International Standards for Vi polysaccharide from Citrobacter freundii and Salmonella enterica subspecies enterica serovar Typhi.
Gao F, et al.
Biologicals : Journal of the International Association of Biological Standardization (2018)
Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.
Olsen JA, et al.
PloS one, 9(3), e91232-e91232 (2014)
Ancestral Reconstruction Approach to Acetylcholine Receptor Structure and Function.
Prinston JE, et al.
Structure, 25(8), 1295-1302 (2017)
Tracey Huynh et al.
Journal of medicinal chemistry, 56(20), 8196-8200 (2013-10-01)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library
Elim Hong et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(52), 21171-21176 (2013-12-12)
The habenulo-interpeduncular pathway, a highly conserved cholinergic system, has emerged as a valuable model to study left-right asymmetry in the brain. In larval zebrafish, the bilaterally paired dorsal habenular nuclei (dHb) exhibit prominent left-right differences in their organization, gene expression

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