M4145

Minoxidil

≥99% (TLC)

• Sinónimos: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Fórmula empírica (notación de Hill): C₉H₁₅N₅O
• Número de CAS: 38304-91-5
• Peso molecular: 209.25
• Número CE: 253-874-2
• Número MDL: MFCD00063409
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277853
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥99% (TLC)
• mp: 272-274 °C (dec.) (lit.)
• emisor: Johnson & Johnson
• cadena SMILES: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• Clave InChI: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Información sobre el gen: human ... KCNJ1(3758)

Descripción

Aplicación

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Acciones bioquímicas o fisiológicas

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302 - H315 - H319 - H335
• Consejos de prudencia: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves