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C1055

Sigma-Aldrich

Cromakalim

Sinónimos:

(±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

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About This Item

Fórmula empírica (notación de Hill):
C16H18N2O3
Número de CAS:
94470-67-4
Peso molecular:
286.33
Número MDL:
MFCD00133201
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24891962
NACRES:
NA.77

Formulario

powder

Nivel de calidad

200

temp. de almacenamiento

2-8°C

cadena SMILES

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

InChI

1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

Clave InChI

TVZCRIROJQEVOT-CABCVRRESA-N

Información sobre el gen

rat ... Kcna1(24520) , Kcnj1(24521) , Kcnj5(29713) , Kcnj8(25472)

Aplicación

Cromakalim has been used:
  • as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
  • as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
  • as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Acciones bioquímicas o fisiológicas

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
13090924
069M4080V
13190201
128M4141V
13180302

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Aravind R Gade et al.
Molecular pharmacology, 83(1), 294-306 (2012-11-02)
The ATP-sensitive potassium channel (K(ATP)) in mouse colonic smooth muscle cell is a complex containing a pore-forming subunit (Kir6.1) and a sulfonylurea receptor subunit (SUR2B). These channels contribute to the cellular excitability of smooth muscle cells and hence regulate the
Hiroyuki Kinoshita et al.
Anesthesia and analgesia, 115(1), 54-61 (2012-04-03)
Adenosine triphosphate (ATP)-sensitive K(+) channels contribute to significant regulatory mechanisms related to organ blood flow in both physiological and pathological conditions. High glucose impairs arterial ATP-sensitive K(+) channel activity via superoxide production. However, the effects of anesthetics on this pathological
Ryuji Tsuburaya et al.
Journal of molecular and cellular cardiology, 51(3), 329-336 (2011-06-10)
Although high intake of n-3 fatty acids is associated with reduced mortality of patients with ischemic heart disease, especially reduction in sudden cardiac death (SCD), the detailed mechanisms remain to be elucidated. Thus, the present study was designed to examine
Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.
Cavero I, et al.
Journal of Pharmacology and Experimental Therapeutics, 248(3), 1261-1268 (1989)
Omonkhelin J Owolabi et al.
Journal of diabetes, 5(1), 88-94 (2013-02-05)
Levcromakalim is a vasorelaxant used in the management of hypertension in diabetes mellitus. Thus, the effects of levcromakalim were investigated in streptozotocin (STZ)-diabetic rats. Diabetes was induced in Wistar albino rats with a single injection of STZ (60 mg/kg, i.p.)
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