L5399

Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant)

• Sinónimos: Diphosphoryl Lipid A from E.Coli.
• Número MDL: MFCD00131510
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 24896402
• NACRES: NA.25

Propiedades

• origen biológico: Escherichia coli (F583 Rd mutant)
• Nivel de calidad: 200
• Formulario: lyophilized powder
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(O)(O)=O)C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(O)(O)=O
• InChI: 1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)
• Clave InChI: GZQKNULLWNGMCW-UHFFFAOYSA-N

Descripción

Descripción general

Lipid A is the fundamental structure of lipopolysaccharides (LPS), present in bacteria.

Aplicación

Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant) has been used:

• to study the effect of various lipid A molecules on lung pericyte proliferation in vitro
• to test on THP-1 and J774A.1 cells for neopterin and nitrite formation respectively
• as lipopolysaccharides (LPS) derivatives in binding experiments
• to stimulate the spleen cells and as a mitogen stimulation for toll like receptor 4 (TLR4)

Acciones bioquímicas o fisiológicas

Lipid A is mainly essential for the robust immunostimulatory activities of lipopolysaccharides (LPS) in human. Lipid A is the hydrophobic domain of LPS helps in anchoring LPS to the plasma membrane of bacteria. It is immunologically active and an important constituent of LPS recognised by immune system.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)