K3125
Kojic acid
≥98.5% (HPLC), powder, tyrosinase inhibitor
Sinónimos:
2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
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About This Item
Fórmula empírica (notación de Hill):
C6H6O4
Número de CAS:
Peso molecular:
142.11
Beilstein:
120895
Número CE:
Número MDL:
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
NACRES:
NA.77
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Nombre del producto
Kojic acid,
Ensayo
≥98.5% (HPLC)
Nivel de calidad
Formulario
powder
mp
152-155 °C (lit.)
cadena SMILES
OCC1=CC(=O)C(O)=CO1
InChI
1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
Clave InChI
BEJNERDRQOWKJM-UHFFFAOYSA-N
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Aplicación
Kojic acid has been used:
- as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
- as a reference inhibitor standard for screening tyrosinase inhibition
- as a positive control for inhibition of tyrosinase in B16F10 melanoma cells
Acciones bioquímicas o fisiológicas
Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.
Tyrosinase inhibitor.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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A series of 46 curcumin related diarylpentanoid analogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinase activities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-gamma/LPS-activated RAW 264.7 cells as compared to L-NAME
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Melanin play a major role in human skin protection and their biosynthesis is vital. Due to their color, they contribute to the skin pigmentation. Tyrosinase is a key enzyme involved in the first stage of melanin biosynthesis, it catalyzes the
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