Todas las fotos(1)

Key Documents

View All Documentation

I9534

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

Name: Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat
Brand: SIGMA

clone 122404, purified immunoglobulin, lyophilized powder

Sinónimos:

Anti-Igf-II, Anti-Igf2, Anti-Mpr, Anti-Peg2

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Todas las fotos(1)

About This Item

Código UNSPSC:

51111800

NACRES:

NA.41

origen biológico

rat

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

122404, monoclonal

formulario

lyophilized powder

reactividad de especies

mouse

técnicas

capture ELISA: 2-8 μg/mL
western blot: 1-2 μg/mL

isotipo

IgG2a

Nº de acceso UniProt

P09535

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

mouse ... Igf2(16002)

Inmunógeno

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Acciones bioquímicas o fisiológicas

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?

Pruebe nuestro Herramienta de selección de productos.

Producto relacionado

Referencia del producto

Descripción

Precios

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.

Robert G Maki

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(33), 4985-4995 (2010-10-27)

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the

IGF2: epigenetic regulation and role in development and disease.

Wendy Chao et al.

Cytokine & growth factor reviews, 19(2), 111-120 (2008-03-01)

Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all

Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications.

C J Rosen

Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)

The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated

Insulin-like growth factor system and sporadic malignant melanoma.

Ettore Capoluongo

The American journal of pathology, 178(1), 26-31 (2011-01-13)

Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico