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I8904

Sigma-Aldrich

Insulin-like Growth Factor-II from mouse

IGF-II, recombinant, expressed in E. coli, lyophilized powder

Sinónimos:

IGF-II

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About This Item

Número MDL:
MFCD00241895
Código UNSPSC:
12352202
NACRES:
NA.77

origen biológico

mouse

Nivel de calidad

100

recombinante

expressed in E. coli

Análisis

>97% (SDS-PAGE)

formulario

lyophilized powder

calidad

endotoxin tested

mol peso

~7.4 kDa

envase

pkg of 5X50 μg
pkg of 50 μg

impurezas

<1.0EUper1mg (LAL test)

Nº de acceso UniProt

P09535

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... IGF2(16002) , Igf2(16002)

Categorías relacionadas

Descripción general

Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.

Acciones bioquímicas o fisiológicas

Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.

Forma física

Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.

Nota de análisis

The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Biyun Qian et al.
Oncology reports, 25(1), 203-213 (2010-11-27)
High expression of insulin-like growth factor-II (IGF-II) in epithelial ovarian cancer is associated with aggressive disease and poor prognosis. IGF-II transcription is initiated from multiple promoters. Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. Here
S D O'Dell et al.
The international journal of biochemistry & cell biology, 30(7), 767-771 (1998-09-02)
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I. The liver is the
Shuo Chen et al.
Cell reports, 32(6), 108007-108007 (2020-08-14)
Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells supporting mesenchymal stem cells (MSCs) are largely unknown. Using

Artículos

Insulin-like Growth Factors (IGF)

Insulin-like Growth Factors (IGF)

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