I8907
Interferon β from rat
≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture
Sinónimos:
IFN-β
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About This Item
Productos recomendados
origen biológico
rat
Nivel de calidad
recombinante
expressed in CHO cells
Ensayo
≥95%
Formulario
lyophilized powder
mol peso
~20 kDa
envase
pkg of 1 vial
concentración
≥100000 units/mL
técnicas
cell culture | mammalian: suitable
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
rat ... Ifnb1(24481)
Acciones bioquímicas o fisiológicas
Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Forma física
Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.
Nota de análisis
The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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C Ren et al.
Gene therapy, 15(21), 1446-1453 (2008-07-04)
Cell-based therapy for cancer is a promising new field. Among cell types that can be used for this purpose, mesenchymal stem cells (MSCs) appear to hold great advantage for reasons including easier propagation in culture, possible genetic modification to express
R B Pepinsky et al.
The Journal of pharmacology and experimental therapeutics, 297(3), 1059-1066 (2001-05-18)
Interferon therapies suffer from a relatively short half-life of the products in circulation. To address this issue we investigated the effects of polyethylene glycol modification (PEGylation) on the pharmacokinetic properties of human interferon (IFN)-beta-1a. PEGylation with a linear 20-kDa PEG
J Adriaansen et al.
Human gene therapy, 17(10), 985-996 (2006-09-21)
Interferon (IFN)-beta has significant immunomodulatory properties and has received much interest as a potentially therapeutic agent for rheumatoid arthritis (RA). Systemic IFN-beta treatment of patients with RA was not effective, probably because of pharmacokinetic issues. Therefore, we studied the effect
Junqiang Ye et al.
PloS one, 6(6), e20681-e20681 (2011-06-17)
The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases. Thus, understanding the mechanisms underlying the negative regulation
Interferon standards and general abbreviations.
S Pestka
Methods in enzymology, 119, 14-23 (1986-01-01)
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