I8026

Anti-Interleukin-8 antibody produced in goat

affinity isolated antibody, lyophilized powder

• Sinónimos: Anti-CXCL8
• Número MDL: MFCD00212220
• Código UNSPSC: 51111800
• NACRES: NA.41

Propiedades

• origen biológico: goat
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: lyophilized powder
• reactividad de especies: human
• técnicas: immunocytochemistry: 5-15 μg/mL; immunohistochemistry: 5-15 μg/mL; neutralization: suitable; western blot: 0.1 μg/mL
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IL8(3576)

Descripción

Descripción general

Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.

Especificidad

The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.

Inmunógeno

recombinant human IL-8 (CXCL8).

Aplicación

Anti-Interleukin-8 antibody can be used for the following :

• For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
• Immunoblotting.
• ELISA.

Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry.

Acciones bioquímicas o fisiológicas

Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.

Forma física

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable