I6760

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse

clone HP-6017, ascites fluid

• Sinónimos: Monoclonal Anti-Human IgG (Fc specific), Anti Human Igg Monoclonal Antibody, Anti-Human Fc Monoclonal Antibody, Anti-Human Fc Monoclonal Antibody - Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse, Mouse Anti-Human Igg
• Código UNSPSC: 12352203
• NACRES: NA.46

Propiedades

• origen biológico: mouse
• conjugado: unconjugated
• forma del anticuerpo: ascites fluid
• tipo de anticuerpo: secondary antibodies
• clon: HP-6017, monoclonal
• contiene: 15 mM sodium azide
• reactividad de especies: rabbit, sheep, horse (IgG), goat, human
• técnicas: indirect ELISA: 1:3,000
• isotipo: IgG2a
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified

Descripción

Descripción general

Monoclonal Anti-Human IgG (mouse IgG2a isotype) is derived from the hybridoma1 produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins (Igs) belongs immunoglobulin super-family and have two heavy (H) and two light (L) chain, held together by disulphide linkages. The four classes of IgG can be IgG1, IgG2, IgG3 and IgG4. Each light chain comprises one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region.

Especificidad

The antibody is specific for the Fc portion of human IgG and recognizes an epitope common to all human IgG subclasses. This antibody was adopted as an Fc specific reagent in the IUIS/WHO study.

Aplicación

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse has been used in:

• enzyme linked immunosorbent assay (ELISA)
• imprint immunofixation (IIF)
• immunofluorometric assay (IFMA)
• hemagglutination (HA)
• hemagglutination inhibition (HAI)
• particle counting immunoassay(PACIA)

Acciones bioquímicas o fisiológicas

Although the antibody site is located in the terminal end of human IgG (part of the Fab fragment), the Fc portion has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess a "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of human IgG.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable