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Documentos clave

I5278

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-3 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Sinónimos:

IGF Binding Protein-3, IGFBP-3

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About This Item

Número MDL:
MFCD00285941
Código UNSPSC:
51111800
NACRES:
NA.32

origen biológico

human

Nivel de calidad

100

recombinante

expressed in NSO cells

Ensayo

≥95% (SDS-PAGE)

Formulario

lyophilized powder

potencia

0.01-0.25 μg/mL

mol peso

29 kDa

envase

pkg of 25 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

endotoxin, tested

Nº de acceso UniProt

P17936

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IGFBP3(3486)

Categorías relacionadas

Acciones bioquímicas o fisiológicas

Human IGFBP-3 is the major insulin-like growth factor (IGF) binding protein in plasma, where it exists in a ternary complex with IGF-I or IGF-II and the acid-labile subunit (ALS).
IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time. IGFBP3 binds to IGF-1. It is a tumor suppressor and is downregulated in many cancers. In serum, IGFs, IGFBP3 and the acid labile subunit (ALS) exist together as a complex. This complex is important for increasing the half life of serum IGFs.

Forma física

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Nota de análisis

The biological acitivity is measured as the ability to inhibit the biological activity of 14 ng/ml recombinant human IGF-I on MCF-7 cells.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302 + H312 + H332,H319

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCL3680
MKCH3657
MKBZ9424V
081M1211
021M1460

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Spagnoli, A. and Rosenfeld, R.G.
Curr. Op. Endocrinology and Diabetes, 4, 1-1 (1997)
Chuan-Wei Yang et al.
Journal of the American Medical Directors Association, 16(5), 365-370 (2014-12-31)
Previous studies have demonstrated the polymorphisms of insulinlike growth factor-1 (IGF-1) and its binding protein-3 (IGFBP3) genes could affect the circulating IGF-1 level. Moreover, the serum IGF-1 level was correlated with muscle size. This study aimed to explore the effect
Kelley, K.M., et al.
The International Journal of Biochemistry & Cell Biology, 28, 619-637 (1995)
Min Sun Kim et al.
Molecular and cellular biochemistry, 403(1-2), 107-113 (2015-02-11)
Nuclear factor-kappaB (NF-κB) is a transcription factor that is activated in various neoplasms, including gastric cancer. Insulin-like growth factor binding protein-3 (IGFBP-3) is a potent tumor suppressor and is significantly suppressed in a variety of cancers. Although IGFBP-3 has been
M L Cubbage et al.
The Journal of biological chemistry, 265(21), 12642-12649 (1990-07-25)
Insulin-like growth factor binding protein-3 (IGFBP-3) can modulate the mitogenic and metabolic effects of the insulin-like growth factors (IGFs). IGFBP-3 protein levels are developmentally regulated and influenced by a number of hormonal stimuli both in vitro and in vivo. As
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