HPA003254

Anti-OLIG2 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinónimos: Anti-Class B basic helix- loop-helix protein 1, Anti-Oligo2, Anti-Oligodendrocyte transcription factor 2, Anti-Protein kinase C-binding protein 2, Anti-Protein kinase C-binding protein RACK17, Anti-bHLHB1
• Código UNSPSC: 12352203
• Atlas de proteínas humanas número: HPA003254
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Línea del producto: Prestige Antibodies^® Powered by Atlas Antibodies
• formulario: buffered aqueous glycerol solution
• reactividad de especies: human
• validación mejorada: orthogonal RNAseq; Learn more about Antibody Enhanced Validation
• técnicas: immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:2500-1:5000
• secuencia del inmunógeno: SPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNI
• Nº de acceso UniProt: Q13516
• aplicaciones: research pathology
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... OLIG2(10215)

Descripción

Descripción general

OLIG2 (oligodendrocyte lineage transcription factor 2) is a transcription factor (TF) belonging to the basic-helix-loop-helix (bHLH) TF family. It is expressed in human glioblastoma and neural progenitor cells. It is a member of the Olig family, and has a predominant expression in ventral spinal cord of human embryo, during initial developmental stages. In spinal cord, it is essential for the maturation of oligodendrocyte progenitor cells.

Inmunógeno

Oligodendrocyte transcription factor 2 recombinant protein epitope signature tag (PrEST)

Aplicación

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-OLIG2 antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Acciones bioquímicas o fisiológicas

OLIG2 (oligodendrocyte lineage transcription factor 2) is expressed in the pMN domain of the spinal cord, where the formation of motoneurons and differentiation of oligodendrocytes occur. Along with Olig1, another protein of the same family, Olig2 participates in specification of neurons, astrocytes, and oligodendrocytes. The gene is mapped to a region on chromosome 21 that has been implicated in learning deficits associated with Down syndrome. It is predominantly expressed in oligodendroglial tumors of the brain and serves as a biomarker for oligodendroglial tumor diagnosis.

Características y beneficios

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Ligadura / enlace

Corresponding Antigen APREST84779

Forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Información legal

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)