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Merck
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Key Documents

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H9415

Sigma-Aldrich

5HPP-33

≥98% (HPLC), solid

Sinónimos:

2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione

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About This Item

Fórmula empírica (notación de Hill):
C20H21NO3
Número de CAS:
105624-86-0
Peso molecular:
323.39
Número MDL:
MFCD03085294
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329815265
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

solid

color

white to off-white

solubilidad

DMSO: >20 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O

InChI

1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3

Clave InChI

LAKWINYVWJPHQW-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

Pictogramas

Environment
GHS09

Palabra de señalización

Warning

Frases de peligro

H410

Consejos de prudencia

P273 - P391 - P501

Clasificaciones de peligro

Aquatic Acute 1 - Aquatic Chronic 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nicole C Kleinstreuer et al.
Environmental health perspectives, 119(11), 1596-1603 (2011-07-27)
Understanding health risks to embryonic development from exposure to environmental chemicals is a significant challenge given the diverse chemical landscape and paucity of data for most of these compounds. High-throughput screening (HTS) in the U.S. Environmental Protection Agency (EPA) ToxCast™
Nicole Kleinstreuer et al.
PLoS computational biology, 9(4), e1002996-e1002996 (2013-04-18)
Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a variety of biological
Takahiro Hamoya et al.
Journal of clinical biochemistry and nutrition, 60(3), 199-207 (2017-06-07)
It is important to establish effective methods for preventing colorectal cancer because the number of colorectal cancer deaths is increasing. Erythromycin one of the macrolide antibiotics, has been shown to exert pleiotropic effects, such as anti-inflammatory and anti-oxidative effects, on
Robert G Ellis-Hutchings et al.
Reproductive toxicology (Elmsford, N.Y.), 70, 82-96 (2017-05-22)
Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High throughput screening (HTS) assays aid AOP development although linking in vitro data to in vivo apical endpoints remains challenging.
Maria Ivshina et al.
Molecular and cellular biology, 35(3), 610-618 (2014-12-03)
The cytoplasmic-element-binding (CPEB) protein is a sequence-specific RNA-binding protein that regulates cytoplasmic polyadenylation-induced translation. In mouse embryo fibroblasts (MEFs) lacking CPEB, many mRNAs encoding proteins involved in inflammation are misregulated. Correlated with this aberrant translation in MEFs, a macrophage cell

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