H6041

Interferon α 2A human

HumanKine^®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyopholized powder, suitable for cell culture

• Sinónimos: α 2A Interferon, Human Interferon α 2A, IFN-α 2A
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• product name: Interferon α 2A human, IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in HEK 293 cells
• Análisis: ≥95% (SDS-PAGE)
• formulario: lyophilized powder
• potencia: ≤0.4 ng/mL EC₅₀
• calidad: endotoxin tested
• mol peso: monomer 16 kDa (glycosylated)
• envase: glass bottle of 10 μg (in glass bottle)
• fabricante / nombre comercial: HumanZyme
• técnicas: cell culture | mammalian: suitable
• impurezas: ≤1EU/mg
• Nº de acceso UniProt: P01563
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IFNA2(3440)

Descripción

Descripción general

The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. It is considered to be a prototypic type I IFN subtype. The encoded protein contains 165 amino acid. Ifna2 protein structure possesses five α-helices, linked by two disulfide bonds.

Aplicación

Interferon α 2A human has been used to check its antiviral action against chikungunya virus. It has also been used as a control to check the antiviral cytokine induction of Korean red ginseng.

Acciones bioquímicas o fisiológicas

IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion.

Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. It has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells.

Forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de preparación

HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Nota de análisis

The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4.

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable