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H4002

Sigma-Aldrich

DL-3-Hydroxynorvaline

≥98% (TLC)

Sinónimos:

HNV, α-Amino-β-hydroxyvaleric acid, 2-Amino-3-hydroxypentanoic acid, 3-Hydroxy-2-aminopentanoic acid, DL-β-Hydroxynorvaline

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About This Item

Fórmula empírica (notación de Hill):
C5H11NO3
Número de CAS:
2280-42-4
Peso molecular:
133.15
Beilstein:
1722350
Número MDL:
MFCD00010516
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de la sustancia en PubChem:
24895609
NACRES:
NA.26

product name

DL-3-Hydroxynorvaline, ≥98% (TLC)

Análisis

≥98% (TLC)

formulario

powder

color

white

aplicaciones

cell analysis

temp. de almacenamiento

−20°C

cadena SMILES

CCC(O)C(N)C(O)=O

InChI

1S/C5H11NO3/c1-2-3(7)4(6)5(8)9/h3-4,7H,2,6H2,1H3,(H,8,9)

Clave InChI

LGVJIYCMHMKTPB-UHFFFAOYSA-N

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Acciones bioquímicas o fisiológicas

3-Hydroxynorvaline (HNV) is a microbial, α amino acid threonine analogue which has antiviral activity (herpes virus) and is toxic to mammalian cells (embryotoxic and teratogenic) presumably via incorporation into proteins. 3-Hydroxynorvaline may be used as an unnatural amino acid to study the fidelity of protein translation at the level of acyl-tRNA editing. 3-Hydroxynorvaline may also be used to study enzymes and molecules involved in threonine metabolism.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palabra de señalización

Danger

Frases de peligro

H315,H318,H335

Clasificaciones de peligro

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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R Kumarasamy et al.
Virology, 138(1), 156-161 (1984-10-15)
Treatment of HSV-infected BHK-21 cells with 5-10 mM of beta-hydroxynorvaline (Hnv), an analog of threonine which blocked attachment of oligosaccharides at the Asn-X-Thr sites, markedly inhibited the synthesis of all viral glycoproteins as well as the major capsid protein. However
Anand Minajigi et al.
Biochemistry, 50(6), 1101-1109 (2011-01-13)
In all living systems, the fidelity of translation is maintained in part by the editing mechanisms of aminoacyl-tRNA synthetases (ARSs). Some nonproteogenic amino acids, including β-hydroxynorvaline (HNV) are nevertheless efficiently aminoacylated and become incorporated into proteins. To investigate the basis
R Counis et al.
Pathologie-biologie, 35(8), 1147-1151 (1987-10-01)
In order to investigate the biosynthetic pathway of LH subunits, anterior pituitary cells were cultured in the presence of [35S]Met and polypeptides immunologically-related (i.r.) to the alpha and LH beta subunits were isolated from cells and media using specific antisera.
C Ramos et al.
Applied and environmental microbiology, 58(5), 1677-1682 (1992-05-01)
In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog alpha-amino-beta-hydroxynorvalerate (hydroxynorvaline), and, of these, the ones able to excrete threonine to the medium were chosen.
R Louw et al.
Amino acids, 29(3), 207-212 (2005-08-06)
3-Hydroxynorvaline (HNV; 2-amino-3-hydroxypentanoic acid), a microbial L-threonine analogue, is toxic to mammalian cells and displays antiviral properties. In view of this, we investigated the toxicity and/or potential teratogenicity of HNV in developing chicken and mouse embryos. HNV was administered to
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