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69453

Sigma-Aldrich

L-Homocysteine

≥98.0% (NT)

Sinónimos:

(S)-2-Amino-4-mercaptobutyric acid

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About This Item

Fórmula lineal:
HSCH2CH2CH(NH2)COOH
Número de CAS:
6027-13-0
Peso molecular:
135.18
Número CE:
227-891-0
Número MDL:
MFCD00151320
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
329761669
NACRES:
NA.32

product name

L-Homocysteine, ≥98.0% (NT)

Nivel de calidad

100

Análisis

≥98.0% (NT)

formulario

powder

actividad óptica

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

color

white

mp

263-265 °C

aplicaciones

cell analysis

enfermedades relevantes

Alzheimer′s disease

temp. de almacenamiento

−20°C

cadena SMILES

N[C@@H](CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1

Clave InChI

FFFHZYDWPBMWHY-VKHMYHEASA-N

Descripción general

L-homocysteine is used to diagnose homocystinuria.

Aplicación

L-homocysteine has been used as a supplement in cell culture media.

Acciones bioquímicas o fisiológicas

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Assessment of homocysteine status
Refsum H, et al.
Journal of inherited metabolic disease, 20(2), 286-294 (1997)
Arpita Basu et al.
Atherosclerosis, 236(1), 188-195 (2014-07-27)
Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and
Ioana Cotlarciuc et al.
Stroke, 45(7), 1920-1924 (2014-05-23)
Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by
James J H Chong et al.
Journal of the American Heart Association, 8(1), e011028-e011028 (2019-01-01)
Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and
Rajendra P Shukla et al.
Advanced healthcare materials, 8(15), e1900462-e1900462 (2019-06-27)
The antipsychotic clozapine is the most effective medication available for schizophrenia and it is the only antipsychotic with a known efficacious clinical range. However, it is dramatically underutilized due to the inability to test clozapine blood levels in finger-pricked patients'
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