Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

H2779

Sigma-Aldrich

HistoChoice® Clearing Agent

greener alternative

alternative to toluene and xylene

Sinónimos:

dewaxing mixture for paraffin tissue sections

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Código UNSPSC:
12171500
NACRES:
NA.47

Nivel de calidad

formulario

liquid

características de los productos alternativos más sostenibles

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

colorless

densidad

0.760-0.820 g/mL

aplicaciones

hematology
histology

categoría alternativa más sostenible

temp. de almacenamiento

room temp

Descripción general

HistoChoice® is a patented, complex mixture of agents that allow tissues to retain their structure, antigenic sites, and nucleic acid sites. It is a non-toxic, non-cross-linking fixative formulated to replace formaldehyde-based fixation. This formulation in non-citrus, contains no mercury, formaldehyde, or glutaraldehyde.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.

Aplicación

HistoChoice® Clearing Agent has the following applications:
  • It is suitable as an alternative to toluene and xylene for dewaxing paraffin tissue sections. Prepared slides are suitable for antibody probing applications and in situ hybridizations.
  • It has been employed in a study to explain the recalcitrance of lignocellulosic plant cell walls to enzymatic degradation.
  • It has been used to develop a novel method to improve sensitivity for the localization of miRNA and their target transcripts in plants.
  • It has been used to study the correlation of cytoplasmic ADP-ribosylation levels with markers of patient outcome in human cancers.

Acciones bioquímicas o fisiológicas

Fixation with HistoChoice® works well in immunohistology applications where its non-cross-linking traits are conducive to epitope retrieval and identification by primary antibodies to extracellular matrix components.

Características y beneficios

  • Non-toxic, non-carcinogenic, and odorless.
  • Non-flammable.
  • Preserves native antigenic and nucleic acid sites.
  • Compatible with many organic mounting media.
  • Dissolves wax faster and evaporates slower than xylene.
  • Can be used in automated processors.
  • Tissues retain their original structure.

Información legal

HistoChoice is a registered trademark of Amresco, Inc.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

142.0 °F

Punto de inflamabilidad (°C)

61.1 °C

Equipo de protección personal

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Sathyanesan Samuel Newton et al.
Brain research. Brain research protocols, 9(3), 214-219 (2002-07-13)
A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. The protocol is specific to sections mounted on glass slides. In contrast to earlier methods that require either paraffin embedding or perfusion of the
Uthpala Apekshani Jayawardena et al.
Environmental toxicology and chemistry, 36(10), 2855-2867 (2017-05-06)
Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban
Agata Jedrzejuk et al.
TheScientificWorldJournal, 2012, 749281-749281 (2012-08-25)
During the vase life of cut stems obstruction of xylem vessels occurs due to microbial growth, formation of tyloses, deposition of materials in the lumen of xylem vessels and the presence of air emboli in the vascular system. Such obstructions
Bjarke Veierskov et al.
American journal of botany, 95(6), 766-771 (2008-06-01)
Meristematic activity in the bud meristem of Abies nordmanniana was visualized by ubiquitin immunohistochemical localization from before bud break and throughout shoot expansion. Ubiquitin was detected in meristematic cells either in the cytosol or nucleus, or both, depending on tissue
Xiaojie Li et al.
Journal of integrative plant biology, 60(1), 45-64 (2017-10-06)
RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat (PPR) proteins. Here, we report the map-based cloning and molecular characterization

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico