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H0266

Sigma-Aldrich

Hemoglobin A2, Ferrous Stabilized human

lyophilized powder

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
eCl@ss:
42030116
NACRES:
NA.61

origen biológico

human

Nivel de calidad

Ensayo

97-100% (agarose gel electrophoresis)

Formulario

lyophilized powder

técnicas

immunofluorescence: suitable

idoneidad

suitable for electrophoresis and chromatography standard

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

human ... HBA2(3040)

Descripción general

Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).

Aplicación

Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.

Acciones bioquímicas o fisiológicas

Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.

Envase

Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).

Reconstitución

When reconstituted with buffer, gives >90% ferrous hemoglobin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Determination of HbA2 by quantitative bottom-up proteomics and isotope dilution mass spectrometry
Arsene C, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 487, 318-324 (2018)
Burçin Nalbantoğlu et al.
Pediatric hematology and oncology, 29(5), 472-478 (2012-08-08)
Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the
Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies
Loucari C, et al.
Human Gene Therapy Methods, 29(1), 60-74 (2018)
Saqib Hussain Ansari et al.
JPMA. The Journal of the Pakistan Medical Association, 62(12), 1314-1317 (2013-07-23)
To screen immediate family members of thalassaemia patients for carrier identification and counselling. The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and involved 188 siblings of 100
Haemoglobin A₂ analysis.
A D Stephens
International journal of laboratory hematology, 35(1), 116-116 (2012-11-20)

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