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G4671

Sigma-Aldrich

Anti-GATA1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1

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About This Item

Número MDL:
MFCD02096392
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

200

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~42 kDa

reactividad de especies

human, rat, mouse

concentración

~1 mg/mL

técnicas

immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000

Nº de acceso UniProt

P15976

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... GATA1(2623)
mouse ... Gata1(14460)
rat ... Gata1(25172)

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Inmunógeno

synthetic peptide corresponding to residues 211-225 of human GATA1.

Aplicación

Anti-GATA1 antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:500 to 1:1000 and for immunohistochemistry at a working dilution of 1:100 to 1:250.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Acciones bioquímicas o fisiológicas

GATA1 belongs to the GATA family of transcription factors. The encoded protein regulates erythroid development and megakaryocyte differentiation. It binds to the consensus sequence 5′-[AT]GATA[AG]-3′ within the regulatory region. Defects in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Reduced levels of GATA1 may cause Diamond-Blackfan anemia.

Forma física

solution in phosphate buffered saline, containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Luciana M Hollanda et al.
Nature genetics, 38(7), 807-812 (2006-06-20)
Acquired somatic mutations in exon 2 of the hematopoietic transcription factor GATA-1 have been found in individuals with Down syndrome with both transient myeloproliferative disorder and acute megakaryoblastic leukemia. These mutations prevent the synthesis of the full-length protein but allow
C D Trainor et al.
Nature, 343(6253), 92-96 (1990-01-04)
Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and
Leif S Ludwig et al.
Nature medicine, 20(7), 748-753 (2014-06-24)
Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA), congenital asplenia and T cell leukemia. Yet, how mutations in genes encoding ubiquitously expressed proteins such as these result in cell-type- and tissue-specific defects remains unknown. Here, we
K E Nichols et al.
Nature genetics, 24(3), 266-270 (2000-03-04)
Haematopoietic development is regulated by nuclear protein complexes that coordinate lineage-specific patterns of gene expression. Targeted mutagenesis in embryonic stem cells and mice has revealed roles for the X-linked gene Gata1 in erythrocyte and megakaryocyte differentiation. GATA-1 is the founding
Fengyun Sun et al.
Development (Cambridge, England), 137(10), 1699-1707 (2010-05-01)
The ENU-induced repro8 mutation was identified in a screen to uncover genes that control mouse gametogenesis. repro8 causes male-limited infertility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition. The repro8 mutation is in the Eif4g3 gene

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