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F9911

Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

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About This Item

Código UNSPSC:
12352202
eCl@ss:
42020141
NACRES:
NA.75

origen biológico

human plasma

Nivel de calidad

200

Ensayo

>90% (SDS-PAGE)

Formulario

lyophilized powder

mol peso

30 kDa

envase

pkg of 0.5 mg

técnicas

cell culture | mammalian: suitable

impurezas

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

solubilidad

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

Nº de acceso UniProt

P02751

Condiciones de envío

ambient

temp. de almacenamiento

−20°C

Información sobre el gen

human ... FN1(2335)

Descripción general

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Aplicación

Fibronectin proteolytic fragment has been used in solid phase binding assay.

Acciones bioquímicas o fisiológicas

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Precaución

The product should be stored at -20°C.

Nota de preparación

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

Opcional

Referencia del producto
Descripción
Precios

F0287

Fibronectina, lyophilized powder, 70 kDa

F0162

Fibronectina, lyophilized powder, 45 kDa

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
069M4158V
11181147
068M4107V
11180231
037M4175V

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S Huff et al.
The Journal of biological chemistry, 269(22), 15563-15570 (1994-06-03)
The N-terminal 29-kDa fragment of fibronectin (Fn29K) contains five type I "finger" modules. It binds to heparin, fibrin, and bacteria and is involved in fibronectin (Fn) matrix assembly. Binding to Staphylococcus aureus involves a cell wall-associated protein that contains approximately
Fibronectin in Health and Disease (2018)
Maryada Sharma et al.
PloS one, 8(7), e69343-e69343 (2013-08-13)
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ. Fibronectin (Fn) is an essential component of the ECM, and plays
E Nègre et al.
The Journal of biological chemistry, 269(35), 22039-22045 (1994-09-02)
A 30-kDa proteolytic fragment from the gelatin/collagen-binding domain of fibronectin is a potent inhibitor of fibronectin binding to Candida albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin
Ming Liu et al.
Scientific reports, 5, 14449-14449 (2015-09-25)
Bacterial adhesins play a pivotal role in the tight bacteria-host cells attachment to initiate the downstream processes and bacterial infection of hosts. In this study, we identified a novel adhesin, VpadF in V. parahaemolyticus. Deletion of VpadF in V. parahaemolyticus
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Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

Protocolos

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs at sigmaaldrich.com

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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