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F7932

Sigma-Aldrich

Famciclovir

≥98% (HPLC)

Sinónimos:

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester, BRL 42810

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About This Item

Fórmula empírica (notación de Hill):
C14H19N5O4
Número de CAS:
104227-87-4
Peso molecular:
321.33
Número MDL:
MFCD00866964
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329799767
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

solid

condiciones de almacenamiento

desiccated

solubilidad

DMSO: ≥10 mg/mL

emisor

Novartis

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O

InChI

1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)

Clave InChI

GGXKWVWZWMLJEH-UHFFFAOYSA-N

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Aplicación

Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.

Acciones bioquímicas o fisiológicas

Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.

Características y beneficios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hanieh Rahimi et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 113(5), 618-627 (2012-06-07)
The purpose of this study was to complete a systematic review and, if possible, a meta-analysis on the effectiveness of systemic and topical nucleoside antiviral agents in the prevention of recurrent herpes labialis (RHL) in immunocompetent subjects. Multiple comprehensive electronic
Dene Simpson et al.
Drugs, 66(18), 2397-2416 (2006-12-22)
Famciclovir (Famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (HSV-1) and 2 (HSV-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (VZV) [a reactivation
Donald C Vinh et al.
Expert opinion on pharmacotherapy, 7(16), 2271-2286 (2006-10-25)
Herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. Herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce
K S Gill et al.
Clinical pharmacokinetics, 31(1), 1-8 (1996-07-01)
Famciclovir is an oral prodrug of the antiherpesvirus nucleoside analogue, penciclovir. Following oral administration famciclovir undergoes extensive first pass metabolism to penciclovir and essentially no parent compound is recovered from plasma or urine. Penciclovir plasma concentrations reach a maximum less
Stephanie Frisch et al.
Pediatric dermatology, 28(1), 46-52 (2011-01-26)
We present 5 cases of eczema herpeticum in patients with severe recalcitrant atopic dermatitis to illustrate the range of possible clinical findings and supporting laboratory data that can obscure the diagnosis and complicate treatment. Major issues include: the need for
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