94330

Uridine 5′-diphosphate disodium salt hydrate

≥96.0% (HPLC)

• Sinónimos: UDP, 5′-UDP-Na₂
• Fórmula empírica (notación de Hill): C₉H₁₂N₂Na₂O₁₂P₂ · xH₂O
• Número de CAS: 27821-45-0
• Peso molecular: 448.12 (anhydrous basis)
• Beilstein: 8817400
• Número CE: 248-678-9
• Número MDL: MFCD00149253
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 57653599
• NACRES: NA.51

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 100
• Análisis: ≥96.0% (HPLC)
• formulario: powder
• impurezas: ≤15% water
• temp. de almacenamiento: −20°C
• cadena SMILES: [Na+].[Na+].[H]O[H].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H14N2O12P2.2Na.H2O/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
• Clave InChI: RHBXRWOXLRCWIZ-LLWADOMFSA-L

Descripción

Aplicación

Uridine 5′-diphosphate disodium salt hydrate has been used:

• as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
• as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
• to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina

Acciones bioquímicas o fisiológicas

Uridine 5′-diphosphate (UDP) is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves