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Merck

F3004

Sigma-Aldrich

Fetuin from fetal calf serum

lyophilized powder

Sinónimos:

Fetuin from fetal calf serum

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

bovine serum (fetal)

formulario

lyophilized powder

técnicas

HPLC: suitable
MALDI-MS: suitable

impurezas

~0.2% free N-acetylneuraminic acid

Nº de acceso UniProt

temp. de almacenamiento

2-8°C

Información sobre el gen

bovine ... FETUB(504615)

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Descripción general

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.

Aplicación

Fetuin from fetal bovine serum has been used:
  • as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
  • as a ligand in carbohydrate binding assay of pertussis toxin vaccine
  • in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies

Acciones bioquímicas o fisiológicas

In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.

Nota de preparación

Further processing of F2379 by gel filtration.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Fetuin-A (alpha2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells
Sakwe AM, et al.
Test, 285(53), 41827-41835 (2010)
Helga Hevér et al.
Methods in molecular biology (Clifton, N.J.), 1934, 93-125 (2019-07-01)
Even if a consensus sequence has been identified for a posttranslational modification, the presence of such a sequence motif only indicates the possibility, not the certainty that the modification actually occurs. Proteins can be glycosylated on certain amino acid side
M Demetriou et al.
The Journal of biological chemistry, 271(22), 12755-12761 (1996-05-31)
The serum glycoprotein fetuin is expressed during embryogenesis in multiple tissues including limb buds and has been shown to promote bone remodeling and stimulate cell proliferation in vitro. In this report, we demonstrate that fetuin antagonizes the antiproliferative action of
Development of an in vitro Biochemical Assay System for the Measurement of Residual Toxin Activities in Pertussis Toxin Containing Vaccines
Ting Yuen C, et al.
Journal of vaccines & vaccination, 08 (2017)
Fetuin-A-Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker
Komsa-Penkova RS, et al.
Journal of Biomedical and Clinical Research, 10(2), 90-97 (2017)

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