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E3651

Sigma-Aldrich

Anti-Endothelin Receptor A antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-ET-A, Anti-ET1-Specific Endothelin Receptor

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About This Item

Número MDL:
MFCD01092540
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

lyophilized powder

reactividad de especies

human, pig, chicken, bovine

técnicas

immunohistochemistry: 1:100 using rat brain sections or rat lung paraffin embedded sections
western blot: 1:200 using rat brain membranes and ECL

Nº de acceso UniProt

P25101

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... EDNRA(1909)
rat ... Ednra(24326)

Especificidad

The epitope is highly conserved in human, swine, bovine and chicken ET-A.

Inmunógeno

synthetic peptide corresponding to amino acids 413-426 of rat ET-A (with additional N-terminal cysteine).

Aplicación

Anti-Endothelin Receptor A antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 using rat brain sections or rat lung paraffin embedded sections and western blotting at a dilution of 1:200 using rat brain membranes and ECL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Acciones bioquímicas o fisiológicas

Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETAR mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

Forma física

Lyophilized from a solution of phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Frases de peligro

H412

Consejos de prudencia

P273

Clasificaciones de peligro

Aquatic Chronic 3

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Shaolin Nie et al.
Molecular carcinogenesis, 53 Suppl 1, E85-E91 (2013-07-03)
The endothelin (ET)-1/endothelin A receptor (ETAR) axis is reportedly involved in tumor cell invasion, survival, and metastasis. However, the role of ETAR in colon cancer metastasis and the underlying mechanisms have not been defined. In the present study, we assessed
H Ohta et al.
British journal of cancer, 100(2), 389-398 (2008-12-25)
We previously reported hedgehog (Hh) signal activation in the mucus-secreting pit cell of the stomach and in diffuse-type gastric cancer (GC). Epithelial-mesenchymal transition (EMT) is known to be involved in tumour malignancy. However, little is known about whether and how
Shaoqing He et al.
Investigative ophthalmology & visual science, 56(10), 6144-6161 (2015-09-24)
A growing body of evidence suggests that the vasoactive peptides endothelins (ETs) and their receptors (primarily the ETB receptor) are contributors to neurodegeneration in glaucoma. However, actions of ETs in retinal ganglion cells (RGCs) are not fully understood. The purpose
S Hori et al.
Endocrinology, 130(4), 1885-1895 (1992-04-01)
Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse functions in both vascular and nonvascular tissues. This investigation concerns the tissue distribution and cellular localization of rat mRNAs encoding two different subtypes of ET receptors (ETA and ETB). We
H Y Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(8), 3185-3189 (1991-04-15)
By screening a cDNA library derived from the A10 rat vascular smooth muscle cell line for functional expression in COS cells, we have isolated a high-affinity receptor for endothelin 1 (Kd = 476 pM) and endothelin 2. The affinity of
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