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E1282

Sigma-Aldrich

Anti-Epidermal Growth Factor Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Sinónimos:

Anti-Egfr, Anti-Erbb, Anti-Errp, Anti-Wa5

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About This Item

Número MDL:
MFCD00162282
Código UNSPSC:
51111800
NACRES:
NA.41

origen biológico

goat

Nivel de calidad

100

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

lyophilized powder

reactividad de especies

mouse

técnicas

immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.25 μg/mL

Nº de acceso UniProt

Q01279

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

mouse ... Egfr(13649)

Categorías relacionadas

Inmunógeno

purified, NSO cell-derived recombinant mouse epidermal growth factor receptor extracellular domain.

Acciones bioquímicas o fisiológicas

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The Journal of clinical investigation, 124(1), 385-397 (2013-12-10)
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Developmental biology, 352(2), 243-253 (2011-02-08)
During the development of the nervous system, the migration of many cells and axons is guided by extracellular molecules. These molecules bind to receptors at the tips of the growth cones of migrating axons and trigger intracellular signaling to steer
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Cuticle formation and molting are critical for the development of Caenorhabditis elegans. To understand cuticle formation more clearly, we screened for suppressors in transgenic worms that expressed dominant ROL-6 collagen proteins. The suro-1 mutant, which is mild dumpy, exhibited a
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Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
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