D3254

7,12-Dimethylbenz[a]anthracene

≥95%

• Sinónimos: 1,4-Dimethyl-2,3-benzophenanthrene, 9,10-Dimethyl-1,2-benzanthracene, DMBA
• Fórmula empírica (notación de Hill): C₂₀H₁₆
• Número de CAS: 57-97-6
• Peso molecular: 256.34
• Beilstein: 1912135
• Número CE: 200-359-5
• Número MDL: MFCD00003600
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24893738
• NACRES: NA.25

Propiedades

• Análisis: ≥95%
• formulario: powder
• mp: 122-123 °C (lit.)
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• cadena SMILES: Cc1c2ccccc2c(C)c3c1ccc4ccccc34
• InChI: 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
• Clave InChI: ARSRBNBHOADGJU-UHFFFAOYSA-N

Descripción

Descripción general

7,12-Dimethylbenz[a]anthracene belongs to the category of polycyclic aromatic hydrocarbons. It is a carcinogenic organic pollutant generated from the incomplete combustion of gasoline and coal.

Aplicación

7,12-Dimethylbenz[a]anthracene was used:

• to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
• in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
• to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12^doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
• to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen

Acciones bioquímicas o fisiológicas

7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H350
• Consejos de prudencia: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Clasificaciones de peligro: Acute Tox. 4 Oral - Carc. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges