C6506

4-Chloro-DL-phenylalanine

• Sinónimos: PCP, PCPA
• Fórmula lineal: ClC₆H₄CH₂CH(NH₂)CO₂H
• Número de CAS: 7424-00-2
• Peso molecular: 199.63
• Número CE: 231-051-9
• Número MDL: MFCD00002601
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24278081
• NACRES: NA.32

Propiedades

• Formulario: solid
• Nivel de calidad: 100
• puntuación de productos alternativos más sostenibles: old score: 2; new score: 1; Find out more about DOZN™ Scoring
• características de los productos alternativos más sostenibles: Less Hazardous Chemical Syntheses; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• mp: >240 °C (dec.) (lit.)
• categoría alternativa más sostenible: , Re-engineered
• temp. de almacenamiento: room temp
• cadena SMILES: NC(Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
• Clave InChI: NIGWMJHCCYYCSF-UHFFFAOYSA-N
• Información sobre el gen: human ... TPH1(7166) , TPH2(121278)

Descripción

Descripción general

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Aplicación

4-Chloro-DL-phenylalanine has been used:

• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Acciones bioquímicas o fisiológicas

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H317
• Consejos de prudencia: P280 - P301 + P310 + P330 - P302 + P352
• Clasificaciones de peligro: Acute Tox. 3 Oral - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges